Application of 33070-32-5, The chemical industry reduces the impact on the environment during synthesis 33070-32-5, name is 5-Bromo-2,2-difluorobenzodioxole, I believe this compound will play a more active role in future production and life.
A solution of 5-bromo-2,2-difluoro-1 ,3-benzodioxole (1.73 mmol), bis(pinacolato)diboron (1.90 mmol), potassium acetate (5.20 mmol), and dichloro[1 ,1′- bis(diphenylphosphino)ferrocene]palladium(ll)?dichloromethane adduct (0.32 mmol) in Lambda/,Lambda/-dimethylformamide (8.0 ml_) was heated at 80 0C for 2 h. The reaction mixture was cooled and was treated with 2-fluoro-4-iodoaniline (0.86 mmol), dichloro[1 ,1 ‘- bis(diphenylphosphino)ferrocene]palladium(ll)?dichloromethane adduct (0.32 mmol), cesium carbonate (8.65 mmol), and water (2.0 mL). The reaction mixture was then heated at 100 0C for 18 h. The reaction mixture was cooled, poured into brine (60 mL), and extracted with (3 x 50 ml.) ethyl acetate. The combined organic layers were dried over magnesium sulfate and decolorizing charcoal, filtered through Celite, and concentrated in vacuo. Purification of the residue by Gilson reverse phase HPLC and neutralization of the collected fractions afforded the title product as a tan solid (70%). ESMS [M+H]+: 267.8.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-2,2-difluorobenzodioxole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; CYTOKINETICS; WO2006/20358; (2006); A2;,
Bromide – Wikipedia,
bromide – Wiktionary