One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene, COA of Formula: C7H6Br2
Cullen, Danica R.;Gallagher, Ashlee;Duncan, Caitlin L.;Pengon, Jutharat;Rattanajak, Roonglawan;Chaplin, Jason;Gunosewoyo, Hendra;Kamchonwongpaisan, Sumalee;Payne, Alan;Mocerino, Mauro research published 《 Synthesis and evaluation of tetrahydroisoquinoline derivatives against Trypanosoma brucei rhodesiense》, the research content is summarized as follows. In this study the synthesis and antitrypanosomal activity of 80 compounds I [X = CH, N; R = H, (R)-HO, C6H5CH2O, etc; R1 = H, HO, C6H5CH2O, etc; R2 = H, HO, 2-cyclohexylethoxy, etc; R3 = H, Me, Et, etc; R4 = H, H3C(H2C)10] based around a core tetrahydroisoquinoline scaffold were reported. A detailed structure activity relationship was revealed, and five derivatives (two of which have been previously reported) with inhibition of T. b. rhodesiense growth in the sub-micromolar range were identified. Four of these I [X = N, R = (R)-HO, R1 = 4-(4-chlorophenyl)phenylmethoxy, R2 = R4 = H, R3 = Me; X = N, R = R2 = R4 = H, R1 = 4-phenylphenyl, R3 = Me; X = N, R = R1 = HO, R2 = (4-phenylphenyl)methoxy, R3 = R4 = H; X = N, R = (R)-HO, R1 = HO, R2 = H, R3 = Me, R4 = H3C(H2C)10] were also found to have good selectivity over mammalian cells (SI > 50). Calculated logD values and preliminary ADME studies predict that these compounds I are likely to have good absorption and metabolic stability, with the ability to passively permeate the blood brain barrier. This makes them excellent leads for a blood-brain barrier permeable antitrypanosomal scaffold.
823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.
3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.
3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., COA of Formula: C7H6Br2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary