Organic compounds having carbon bonded to bromine are called organic bromides. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Related Products of 402-49-3.
Cao, Lianyi;Hu, Fangzhi;Sun, Hongmei;Zhang, Xiaomei;Li, Shuai-Shuai research published 《 Redox-triggered dearomative [5 + 1] annulation of indoles with O-alkyl ortho-oxybenzaldehydes for the synthesis of spirochromanes》, the research content is summarized as follows. The dearomative [5 + 1] annulation of 2-methylindoles I (R = H, 4-Me, 5-F, 6-OMe, etc.) with new five-membered synthons O-alkyl ortho-oxybenzaldehydes II (R1 = t-Bu, propan-2-yl, butan-2-yl; R2 = H, Me, t-Bu; R3 = Me, ethenyl, Ph, naphthalen-2-yl, etc.; R4 = H, Me) was developed unprecedentedly through cascade [1,5]-hydride transfer/dearomative cyclization in HFIP for the synthesis of spirochromanes III bearing the 2-methylindolenine skeleton. In addition, the dual alkylation of the Me group of 2-methylindolenines was achieved by sequential operation through the redox neutral [5 + 1] annulation with the second five-membered synthon N-alkyl ortho-aminobenzaldehydes IV (R5 = Me; R6 = Et; R5R6 = -(CH2)4-; R7 = H, Cl), providing the chromane and tetrahydroquinoline fused spiroindolenines V in good yields. Furthermore, the auxiliary group that facilitates the hydride transfer process could be simply removed.
402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., Related Products of 402-49-3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary