A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Product Details of C5H9BrO2.
Campiani, Giuseppe;Cavella, Caterina;Osko, Jeremy D.;Brindisi, Margherita;Relitti, Nicola;Brogi, Simone;Saraswati, A. Prasanth;Federico, Stefano;Chemi, Giulia;Maramai, Samuele;Carullo, Gabriele;Jaeger, Benedikt;Carleo, Alfonso;Benedetti, Rosaria;Sarno, Federica;Lamponi, Stefania;Rottoli, Paola;Bargagli, Elena;Bertucci, Carlo;Tedesco, Daniele;Herp, Daniel;Senger, Johanna;Ruberti, Giovina;Saccoccia, Fulvio;Saponara, Simona;Gorelli, Beatrice;Valoti, Massimo;Kennedy, Breandan;Sundaramurthi, Husvinee;Butini, Stefania;Jung, Manfred;Roach, Katy M.;Altucci, Lucia;Bradding, Peter;Christianson, David W.;Gemma, Sandra;Prasse, Antje research published 《 Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors》, the research content is summarized as follows. Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by a progressive-fibrosing phenotype. IPF has been associated with aberrant HDAC activities confirmed by our immunohistochem. studies on HDAC6 overexpression in IPF lung tissues. We herein developed a series of novel hHDAC6 inhibitors, having low inhibitory potency over hHDAC1 and hHDAC8, as potential pharmacol. tools for IPF treatment. Their inhibitory potency was combined with low in vitro and in vivo toxicity. Structural anal. of 6h (I) and structure-activity relationship studies contributed to the optimization of the binding mode of the new mols. The best-performing analogs were tested for their efficacy in inhibiting fibrotic sphere formation and cell viability, proving their capability in reverting the IPF phenotype. The efficacy of analog 6h was also determined in a validated human lung model of TGF-β1-dependent fibrogenesis. The results highlighted in this manuscript may pave the way for the identification of first-in-class mols. for the treatment of IPF.
4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Product Details of C5H9BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary