One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene, Electric Literature of 402-49-3
Bokhtia, Riham M.;Girgis, Adel S.;Ibrahim, Tarek S.;Rasslan, Fatma;Nossier, Eman S.;Barghash, Reham F.;Sakhuja, Rajeev;Abdel-Aal, Eatedal H.;Panda, Siva S.;Al-Mahmoudy, Amany M. M. research published 《 Synthesis, Antibacterial Evaluation and Computational Studies of a Diverse Set of Linezolid Conjugates》, the research content is summarized as follows. A total of 31 diverse linezolid conjugates I [R = 4-FC6H4CH2, Bz, pyridine-4-carbonyl, etc.] were synthesized using established benzotriazole chem. with good yield and purity. Some of the synthesized conjugates exhibited promising antibacterial properties against different strains of bacteria. Among all the synthesized compounds, compound I [R = 4-O2NC6H4C(O)] was the most promising antibacterial agent with MIC 4.5μM against S. aureus and 2.25μM against B. subtilis. Using exptl. data pool, a robust QSAR (R2 = 0.926, 0.935; R2cvOO = 0.898, 0.915; R2cvMO = 0.903, 0.916 for the S. aureus and B. subtilis models, resp.) and 3D-pharmacophore models were developed. The drug-like properties of the synthesized conjugates using computational tools were also determined These findings provided valuable insight into the possible linezolid-based antibiotic drug candidates.
Electric Literature of 402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary