Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Product Details of C5H7BrO3.
Alzain, Abdulrahim A.;Brisson, Lucie;Delaye, Pierre-Olivier;Penichon, Melanie;Chadet, Stephanie;Besson, Pierre;Chevalier, Stephan;Allouchi, Hassan;Mohamed, Magdi A.;Roger, Sebastien;Enguehard-Gueiffier, Cecile research published 《 Bioinspired imidazo[1,2-a:4,5-c’]dipyridines with dual antiproliferative and anti-migrative properties in human cancer cells: The SAR investigation》, the research content is summarized as follows. Design, synthesis and evaluation of novel bioinspired imidazo[1,2-a:4,5c’]dipyridines I [X = Br or I; R1 = Me, Et, Ph, etc.; R2 = c-Pr, t-Bu, Ph, etc.; R3 = H, Me, Br, etc.; R4 = H, Et, Bn]. The structural optimization identified four anti-proliferative compounds Compounds I [X = Br or I; R1 = Me, MeO, R2 = Ph, t-Bu, c-Pr, R3 = H, R4 = Bn] exhibited excellent anticancer activities in vitro with IC50 of 0.4-5μM against three human cancer cell lines (MDA-MB-468, MDA-MB-435s and MDA-MB-231). These I [X = Br or I; R1 = Me, MeO, R2 = Ph, t-Bu, c-Pr, R3 = H, R4 = Bn] induced apoptosis in MDA-MB-231 cells in a dose-dependent manner, targeting different apoptotic proteins expression: I [R1 = Me, R2 = Ph, R3 = H, R4 = Bn] increased the expression of pro-apoptotic Bax protein while 18-20 reduced the level of anti-apoptotic Bcl-2 protein. Compounds I [X = Br; R1 = MeO, R2 = t-Bu, c-Pr, R3 = H, R4 = Bn] also reduced MDA-MB-231 cells proliferation as measured by Ki-67 staining. Furthermore, compounds were also tested for the ability to inhibit cell migration in the highly aggressive human MDA-MB-435s cell line. Six compounds of this series I [X = Br; R1 = Me, Ph, MeO, HO, Et, R2 = t-Bu, Ph, c-Pr, R3 = H, Br, R4 = Bn] inhibited cell migration by 41-50% while four compounds I [X = Br; R1 = MeO, Ph, R2 = Ph, t-Bu, R3 = H, Br, Ph, 1-benzyl pyridinium-4-yl, R4 = Bn, H] inhibited the migration by 53-62% in wound-healing experiments Interestingly, compound I [X = Br, R1 = OMe, R2 = Ph, R3 = H, R4 = Bn]. presented both antiproliferative and anti-migration activities and were promising anti-metastatic agent for cancer treatment.
Product Details of C5H7BrO3, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.
Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.
Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary