61613-22-7, name is 2-Bromo-N-phenylaniline, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C12H10BrN
2-Bromo-N-phenylaniline (10 g) was dissolved inAfter 100 ml THF (tetrahydrofuran), the reaction temperature is lowered to -78 C,20 ml of 2.5 M BuLi (butyllithium) was slowly added dropwise and stirred for 1 hour.Dissolving 15.2 g of bis(4-chlorophenyl)methanone (bis(4-chlorophenyl)methanone)After 150 ml of THF (tetrahydrofuran) was slowly added dropwise,The temperature was raised to room temperature and stirred for 12 hours. After the reaction is over,A solid obtained by extracting with distilled water and MC (dichloromethane) and removing water by using anhydrous magnesium sulfate and then filtering under reduced pressure is directly dissolved in 150 ml of acetic acid (Acetic acid) without further purification.10 ml of sulfuric acid was added dropwise and stirred under reflux. After the reaction is over,Extraction with distilled water and MC (dichloromethane) and column purification of the resulting solid10g I3. (yield 62%)
The synthetic route of 61613-22-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dongjin Shimeiken Co., Ltd.; Xian Haowan; An Xianzhe; Jin Bingyu; Han Zhengyou; Jin Jintai; (31 pag.)CN104471022; (2018); B;,
Bromide – Wikipedia,
bromide – Wiktionary