Shaban, Nema S.;Radi, Abeer M.;Bogzil, Alsadek H.;El-Banna, H. A.;Mobarez, Elham Ahmed;El-Gendy, A. A. M. published 《Effect of bromhexine on the pharmacokinetic of tilmicosin in broiler chickens》. The research results were published in《Biomedical and Pharmacology Journal》 in 2019.Synthetic Route of C14H21Br2ClN2 The article conveys some information:
Concurrent administration of drugs may alter their pharmacokinetic parameters, so; investigation to what extent bromhexine hydrochloride affects the pharmacokinetic behavior of tilmicosin was our aim of this work. Ten broiler chickens were classified into two groups as follow, the first one (tilmicosin group) was given single oral dose of tilmicosin (20 mg/kg.b.weight) while the 2nd (pre-treated group) was given single oral dose of bromhexine hydrochloride (1 mg/kg.b.weight) followed by single oral dose of tilmicosin (20 mg/kg.b.weight) one hour later. The serum concentration of tilmicosin was measured using High Pressure Liquid Chromatog. (HPLC) method. The results revealed that the mean serum concentrations of tilmicosin were significantly lower in pre-treated group when compared with tilmicosin alone group at the corresponding time intervals. Pharmacokinetic parameters were significantly differed (p<0.001) between both groups. The maximum serum concentration were (Cmax 0.70 ± 0.02, 0.81 ± 0.04μg/mL), achieved at Tmax of (tmax 0.89 ± 0.16, and 2.10 ± 0.06h), absorption half-life (t0.5ab) of 0.16 ± 0.08, and 0.37 ± 0.01 h, area under curve (AUC) of 12.96 ± 0.42 and 16.73 ± 0.42μg.h/mL) in tilmicosin-bromhexine and tilmicosin alone groups resp. In conclusion, based on the obtained pharmacokinetic parameters, these findings showed that bromhexine accelerates the tilmicosin penetration into body tissues, achieving higher and faster concentrations than when given tilmicosin alone. The experimental procedure involved many compounds, such as 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .
2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) (BHH; 250μM; 24 hours) also significantly attenuates HGF-induced invasion of LNCaP and C4-2B cells that natively express TMPRSS2. No significant toxicity is observed over a 48-hour period exposing LNCaP, DU145, PC3, or HepG2 cells to Bromhexine hydrochloride concentrations ranging from 0μM to 250μM. Bromhexine hydrochloride exposure does not induce cell death or substantially suppress the growth of DU145 cells.Bromhexine hydrochloride (20 μM; 48 h) inhibits dendritic cells infection with HIV-1.Synthetic Route of C14H21Br2ClN2
Reference:
Bromide – Wikipedia,
bromide – Wiktionary