The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline(SMILESS: C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3,cas:837-52-5) is researched.Recommanded Product: 1001-26-9. The article 《Synthesis and characterization of impurities present in an antimalarial drug piperaquine phosphate》 in relation to this compound, is published in Indian Journal of Heterocyclic Chemistry. Let’s take a look at the latest research on this compound (cas:837-52-5).
Six impurities formed during the process development of piperaquine phosphate, were identified as 7-chloro-4-(piperazine-1-yl)quinoline, 3-(4-(7-chloroquinolin-4-yl)piperazine-1-yl)propan-1-ol, 7-chloro-4-(4-(3-ethoxypropyl)piperazine-1-yl)quinoline, 1,4-bis(7-chloro-4-quinolinyl)piperazine, I [X = (CH2)3] and II by LC-MS. The structures of these impurities were further confirmed by synthesis. HPLC anal. of piperaquine phosphate API showed impurities ranging from 0.05 to 0.22%.
Different reactions of this compound(7-Chloro-4-(piperazin-1-yl)quinoline)Reference of 7-Chloro-4-(piperazin-1-yl)quinoline require different conditions, so the reaction conditions are very important.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary