So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lavrard, Hubert; Larini, Paolo; Popowycz, Florence researched the compound: Ethyl 3-Ethoxy-2-Propenoate( cas:1001-26-9 ).Safety of Ethyl 3-Ethoxy-2-Propenoate.They published the article 《Superacidic Cyclization of Activated Anthranilonitriles into 2-Unsubstituted-4-aminoquinolines》 about this compound( cas:1001-26-9 ) in Organic Letters. Keywords: aminoquinoline preparation superacidic cyclization activated anthranilonitrile; condensation anthranilonitrile trichloroethoxybutenone theor investigation. We’ll tell you more about this compound (cas:1001-26-9).
4-Aminoquinolines were prepared in a three-step synthesis starting from substituted anthranilonitriles. The condensation on 1,1,1-trichloro-4-ethoxybut-3-enone proceeded efficiently either neat or in refluxing EtOH. Cyclization in superacidic trifluoromethanesulfonic acid provided unstable intermediate, which upon treatment with NaOEt in ethanol, afforded the expected esters. Theor. investigations pointed out a monoprotonated nitrilium as the reactive species during the cyclization process.
After consulting a lot of data, we found that this compound(1001-26-9)Safety of Ethyl 3-Ethoxy-2-Propenoate can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary