So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Dongre, Vaijanath G.; Karmuse, Pravin P.; Ghugare, Pradeep D.; Gupta, Mukesh; Nerurkar, Bipin; Shaha, Chirag; Kumar, Ashok researched the compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5 ).Electric Literature of C13H14ClN3.They published the article 《Characterization and quantitative determination of impurities in piperaquine phosphate by HPLC and LC/MS/MS》 about this compound( cas:837-52-5 ) in Journal of Pharmaceutical and Biomedical Analysis. Keywords: piperaquine phosphate impurity HPLC mass spectrometry stability degradation. We’ll tell you more about this compound (cas:837-52-5).
Four impurities in piperaquine phosphate bulk drug substance were detected by a newly developed gradient reverse phase high performance liquid chromatog. (HPLC) method. These impurities were identified by LC/MS/MS. The structures of impurities were confirmed by spectroscopic studies (NMR and IR) conducted using synthesized authentic compounds The synthesized reference samples of the impurity compounds were used for the quant. HPLC determination The system suitability of HPLC anal. established the validity of the separation The method was validated according to ICH guidelines with respect to specificity, precision, accuracy and linearity. Forced degradation studies were also performed for piperaquine phosphate bulk drug samples to demonstrate the stability indicating power of the newly developed HPLC method.
In some applications, this compound(837-52-5)Electric Literature of C13H14ClN3 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary