Category: bromides-buliding-blocks. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Antiplasmodial and antitumor activity of dihydroartemisinin analogs derived via the aza-Michael addition reaction. Author is Feng, Tzu-Shean; Guantai, Eric M.; Nell, Margo J.; van Rensburg, Constance E. J.; Hoppe, Heinrich C.; Chibale, Kelly.
A series of dihydroartemisinin derivatives were synthesized via an aza-Michael addition reaction to a dihydroartemisinin-based acrylate and were evaluated for antiplasmodial and antitumor activity. The target compounds showed excellent antiplasmodial activity, with four of the dihydroartemisinin derivatives exhibiting IC50 values of ≤10 nM against both D10 and Dd2 strains of Plasmodium falciparum. Derivative I was the most active against the HeLa cancer cell line, with an IC50 of 0.37 μM and the highest tumor specificity.
In some applications, this compound(837-52-5)Category: bromides-buliding-blocks is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary