The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol, is researched, Molecular C20H12Br2O2, CAS is 119707-74-3, about Asymmetric Petasis Reactions Catalyzed by Chiral Biphenols, the main research direction is alkenyl boronate asym Petasis reaction secondary amine glyoxylate biphenol; amino ester unsaturated asym synthesis.Synthetic Route of C20H12Br2O2.
Chiral biphenols catalyze the enantioselective Petasis reaction of alkenyl boronates R1R2C:CHB(OEt)2 (R1 = n-Bu, cyclohexyl, Ph, 4-MeOC6H4, 3-thienyl, etc., R2 = H; R1 = n-Bu, Ph, R2 = Me), secondary amines R3R4NH (R3 = PhCH2, R4 = Me, t-Bu, CH2CH2CN, EtO2C, Me3Si, PhCH2, etc.; R3 = R4 = allyl; etc.), and Et glyoxylate. The reaction requires the use of 15 mol % of (S)-VAPOL as the catalyst, alkenyl boronates as nucleophiles, Et glyoxylate as the aldehyde component, and 3A mol. sieves as an additive. The chiral α-amino ester products R1R2C:CHCH(NR3R4)CO2Et were obtained in good yields (71-92%) and high enantiomeric ratios (89:11-98:2). Mechanistic investigations indicate single ligand exchange of acyclic boronate with VAPOL and tetracoordinate boronate intermediates.
In some applications, this compound(119707-74-3)Synthetic Route of C20H12Br2O2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary