Recommanded Product: 33216-52-3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3,4,5-Trichloropyridine, is researched, Molecular C5H2Cl3N, CAS is 33216-52-3, about Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47. Author is Weinstock, Joseph; Wu, Jian; Cao, Ping; Kingsbury, William D.; McDermott, Jeffrey L.; Kodrasov, Matthew P.; McKelvey, Devin M.; Suresh Kumar, K. G.; Goldenberg, Seth J.; Mattern, Michael R.; Nicholson, Benjamin.
Inhibitors of the cancer-related cysteine isopeptidase human ubiquitin-specific proteases 7 (USP7) and 47 (USP47) are considered to have potential as cancer therapeutics, owing to their ability to stabilize the tumor suppressor p53 and to decrease DNA polymerase β (Polβ), both of which are potential anticancer effects. A new class of dual small mol. inhibitors of these enzymes has been discovered. Compound 1 (I), a selective inhibitor of USP7 and USP47 with moderate potency, demonstrates inhibition of USP7 in cells and induces elevated p53 and apoptosis in cancer cell lines. Compound 1 has been shown to demonstrate modest activity in human xenograft multiple myeloma and B-cell leukemia in vivo models. This activity may be the result of dual inhibition of USP7 and USP47. To address issues regarding potency and developability, analogs of compound 1 have been synthesized and tested, leading to improvements in potency, solubility, and metabolic reactivity profile. Further optimization is expected to yield preclin. candidates and, ultimately, clin. candidates for the treatment of multiple myeloma, prostate cancer, and other cancers.
In addition to the literature in the link below, there is a lot of literature about this compound(3,4,5-Trichloropyridine)Recommanded Product: 33216-52-3, illustrating the importance and wide applicability of this compound(33216-52-3).
Reference:
Bromide – Wikipedia,
bromide – Wiktionary