The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Synthesis and bioevaluation of novel 4-aminoquinoline-tetrazole derivatives as potent antimalarial agents, the main research direction is aminoquinoline tetrazole preparation antimalarial malaria treatment Plasmodium falciparum; 4-Aminoquinoline; Antimalarial; Chloroquine; Cytotoxicity; Tetrazole.Safety of 7-Chloro-4-(piperazin-1-yl)quinoline.
A series of novel tetrazole derivatives of 4-aminoquinoline were synthesized and screened for their antimalarial activities against both chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum as well as for cytotoxicity against VERO cell lines. Most of the synthesized compounds exhibited potent antimalarial activity as compared to chloroquine against K1-strain. Compounds with significant in vitro antimalarial activity were then evaluated for their in vivo efficacy in Swiss mice against Plasmodium yoelii following both i.p. (i.p.) and oral administration, wherein compounds I (R = Cl or Br) each showed in vivo suppression of 99.99% parasitemia on day 4.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary