The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol( cas:119707-74-3 ) is researched.HPLC of Formula: 119707-74-3.Liu, Tian-Lin; Zhang, Heng-Xia; Zheng, Yan; Yao, Qingwei; Ma, Jun-An published the article 《Catalytic enantioselective addition of terminal 1,3-diynes to N-sulfonyl aldimines: access to chiral diynylated carbinamines》 about this compound( cas:119707-74-3 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: methylzinc binol catalytic enantioselective addition terminal diyne sulfonyl aldimine; chiral diynylated carbinamine preparation hydrogenation reduction; crystal structure chiral bromophenyl phenylpentadiynyl benzenesulfonamide; mol structure chiral bromophenyl phenylpentadiynyl benzenesulfonamide. Let’s learn more about this compound (cas:119707-74-3).
An efficient method for the asym. synthesis of chiral diynylated carbinamines is described. The direct catalytic enantioselective addition of terminal 1,3-diynes to N-sulfonyl aldimines proceeded smoothly under mild reaction conditions to produce diynylated carbinamines in up to 98% yield and 99% ee. E.g., reaction N-tosyl benzaldimine with phenylbuta-1,3-diyne in the presence of 2 equivalent of Me2Zn and 20 mol% of (S)-1,1′-bi-2-naphthol in toluene at 25° to give 96% yield of N-(1,5-diphenylpenta-2,4-diyn-1-yl)-4-methylbenzenesulfonamide.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary