So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Qu, Bo; Haddad, Nizar; Rodriguez, Sonia; Sieber, Joshua D.; Desrosiers, Jean-Nicolas; Patel, Nitinchandra D.; Zhang, Yongda; Grinberg, Nelu; Lee, Heewon; Ma, Shengli; Ries, Uwe Jorg; Yee, Nathan K.; Senanayake, Chris H. researched the compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol( cas:119707-74-3 ).Application In Synthesis of (S)-3,3′-Dibromo-1,1′-bi-2-naphthol.They published the article 《Ligand-Accelerated Stereoretentive Suzuki-Miyaura Coupling of Unprotected 3,3′-Dibromo-BINOL》 about this compound( cas:119707-74-3 ) in Journal of Organic Chemistry. Keywords: stereoretentive Suzuki unprotected bromo BINOL enantioselective synthesis arylated BINOL; ligand accelerated palladium catalyzed stereoretentive Suzuki bromo BINOL. We’ll tell you more about this compound (cas:119707-74-3).
An efficient synthesis of the enantiomerically pure 3,3′-bis-arylated BINOL derivatives is accomplished through the palladium-catalyzed Suzuki-Miyaura coupling of the unprotected 3,3′-dibromo-BINOL with complete retention of enantiopurity. The active catalyst system Pd(OAc)2/BI-DIME [BI-DIME = I, (S)- or (±)-I] has enabled mild reaction conditions at palladium loads as low as 500 ppm.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary