Shi, Xiaolin; Li, Xiaowei; Ma, Lina; Shi, Dayong published an article about the compound: 6-Bromo-3-methyl-1H-indole( cas:1219741-50-0,SMILESS:CC1=CNC2=C1C=CC(Br)=C2 ).Application of 1219741-50-0. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1219741-50-0) through the article.
An efficient copper-catalyzed oxidative trifluoromethylation of indoles I (R1 = H, Boc, Bn, Bz; R2 = Me, cyclohexyl, CH2C(O)CH3, CH2CN, etc.; R3 = H, 4-F, 5-MeO, 6-Cl, 7-Br, etc.) with low-cost CF3SO2Na via C-H activation has been described. Notably, the use of a base is crucial for the trifluoromethylation of indoles I. This reaction proceeds efficiently in good to excellent yields and is tolerance of a broad range of functional groups. Furthermore, melatonin, a medicine for sleep disorders, is converted to its 2-CF3 analog in 68% yield. Studies of possible reaction pathways suggest that this reaction proceeds through a radical process.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary