1647-26-3,Some common heterocyclic compound, 1647-26-3, name is 1-Bromo-2-cyclohexylethane, molecular formula is C8H15Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Dissolve (2-bromo-ethyl) -cyclohexane (10.0 g, 52.3 mmol) in 500 mL acetone, add sodium iodide (15.6 g, 104.6 mmol) and reflux over night. Filter the reaction mixture, add water to the filtrate and extract with hexane. Dry the organic phases over sodium sulfate, filter and concentrate to an oil. Further purify this material by distillation to afford the title compound (10.6 G). 1H-NMR (CDC13) 8= 0.83-1. 00 (M, 2H), 1.07-1. 48 (M, 4H), 1.61- 1.80 (M, 7H), 3.16-3. 27 (M, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2-cyclohexylethane, its application will become more common.
Reference:
Patent; ELI LILLY AND COMPANY; WO2004/63179; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary