Category: bromides-buliding-blocks. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Ethyl 3-Ethoxy-2-Propenoate, is researched, Molecular C7H12O3, CAS is 1001-26-9, about Development of orally active nonpeptidic inhibitors of human neutrophil elastase. Author is Ohmoto, Kazuyuki; Yamamoto, Tetsuya; Okuma, Motohiro; Horiuchi, Toshihide; Imanishi, Hirotoshi; Odagaki, Yoshihiko; Kawabata, Kazuhito; Sekioka, Tomohiko; Hirota, Yasushi; Matsuoka, Shozo; Nakai, Hisao; Toda, Masaaki; Cheronis, John C.; Spruce, Lyle W.; Gyorkos, Albert; Wieczorek, Maciej.
5-Amino-2-phenylpyrimidin-6-ones, some desamino derivatives, miscellaneous derivatives, and oxadiazoles were synthesized and biol. evaluated on both in vitro activity and oral activity in an acute hemorrhagic assay. The aminophenylpyrimidinones contained an α-keto-1,3,4-oxadiazole moiety to bind covalently to the Ser-195 hydroxy group of human neutrophil elastase (HNE), an enzyme whose excess is believed to contribute to inflammatory diseases such as emphysema. Many of the aminophenylpyrimidinones tested showed useful pharmacokinetic profiles when given orally to rats. Oxadiazolyl pyrimidine I was selected for clin. evaluation based on its oral potency, duration of action, enzyme selectivity, safety profile, and ease of synthesis. Structure-activity relationships of the inhibition of aminophenylpyrimidinone derivative binding to HNE are discussed.
As far as I know, this compound(1001-26-9)Category: bromides-buliding-blocks can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary