Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2645-22-9, is researched, Molecular C10H8N2S2, about Trimethylsilyl reporter groups for NMR studies of conformational changes in G protein-coupled receptors, the main research direction is trimethylsilyl NMR GPCR conformational change; G protein-coupled receptor; nuclear magnetic resonance; trimethylsilylmethanethiol; β2-adrenergic receptor.Name: 4,4-Dipyridyl Disulfide.
Large membrane proteins such as G protein-coupled receptors (GPCRs) are difficult for NMR study due to severe signal overlaps and unfavorable relaxation properties. The authors used a trimethylsilyl (TMS) group as a reporter group for 1H NMR study of conformational changes in proteins, using high-intensity 1H NMR signals near 0 p.p.m. The β2-adrenergic receptor was labeled with TMS groups at two cysteines located at the cytoplasmic ends of helixes VI and VII. Binding of various ligands led to changes in 1H NMR signals, which manifested that helix VI is sensitive to G protein-specific activation, whereas helix VII is sensitive to β-arrestin-specific activation. Thus, the TMS group is a useful reporter group in NMR for studying conformational changes in membrane proteins such as GPCRs.
There is still a lot of research devoted to this compound(SMILES：C1(SSC2=CC=NC=C2)=CC=NC=C1)Name: 4,4-Dipyridyl Disulfide, and with the development of science, more effects of this compound(2645-22-9) can be discovered.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary