Application of 1786-36-3,Some common heterocyclic compound, 1786-36-3, name is (2-Bromo-1-fluoroethyl)benzene, molecular formula is C8H8BrF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Accordingly, using the Formula-XXVII bicyclo compound wherein -Ct H2t represents alkylene substituted with one or 2 fluoro, for example the bicyclo compound prepared by the procedures of Preparation 1 and Example 1 from (2-bromo-1-fluoroethyl)benzene, (5-bromo-4-fluoropentyl)benzene, or (6-bromo-5,5-difluorohexyl)benzene there are obtained compounds corresponding to the products of Example 3 wherein -Ct H 2t – represents alkylene substituted with one or 2 fluoro. Accordingly, using the Formula-XXVII bicyclo compounds wherein (T)s on the phenyl ring is alkyl of one to 4 carbon atoms, inclusive, fluoro, chloro, trifluoromethyl, or OR9 wherein R9 is hydrogen, alkyl of one tp 4 carbon atoms, inclusive, or tetrahydropyranyl, and s is one, 2, or 3, for example Formula-XXVII bicyclo compounds wherein (T)s is 2-methyl, 2,4,6-trimethyl,2-chloro,3-trifluoromethyl, or 3,4-dimethoxy, there are obtained compounds corresponding to the products of Example 3.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (2-Bromo-1-fluoroethyl)benzene, its application will become more common.
Reference:
Patent; The Upjohn Company; US3987087; (1976); A;,
Bromide – Wikipedia,
bromide – Wiktionary