Synthetic Route of 1647-26-3, A common heterocyclic compound, 1647-26-3, name is 1-Bromo-2-cyclohexylethane, molecular formula is C8H15Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 2; Synthesis of 3-(2-aminoquinazolin-6-yl)-1-(2-cyclohexylethyl)-4- methylpyridin-2(1 K)-one; To a solution of 3-(2-aminoquinazolin-6-yl)-4-methylpyridin-2(1 H)-one (103mg, 408 mumol, Example 1 , step 3) in DMF in a sealed tube was added sodium tert- butoxide (58.9 mg, 612 mumol). The mixture was stirred at RT for 5min and turned from clear yellow to a suspension of yellow solids. 1-bromo-2-cyclohexylethane (76.7 mul, 490 mumol) was then added and the resulting mixture was heated to 700C over the weekend. Reaction was cooled to RT and was quenched with Sat’d NH4CI and extracted with DCM. Purification by prep plate TLC (10% MeOH/DCM) produced the title compound as an off white solid. M+H= 363.2.
The synthetic route of 1647-26-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; WO2008/11109; (2008); A2;,
Bromide – Wikipedia,
bromide – Wiktionary