1435-51-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1435-51-4 as follows.
step 1-A solution of 57a, sodium methoxide (1 equivalent) and DMF were stirred overnight under an N2 atmosphere at RT. The volatile solvents were removed in vacuo and the residue partitioned between Et2O and water. The organic phase was washed with 5% NaOH, water and brine, dried (MgSO4), filtered and evaporated to afford 57b.
According to the analysis of related databases, 1,3-Dibromo-5-fluorobenzene, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Roche Palo Alto LLC; US2006/25462; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary