Reference of 185122-74-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 185122-74-1, name is 5-Bromo-2,3-dihydro-1H-inden-1-amine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
2.7 g of 5-bromoindan-1-ylamine were dissolved in 30 ml of dichloromethane. 2.2 g of pyridine were added to this solution followed by the addition of 1.4 g of propionic anhydride while cooling with ice. After returning the reaction solution to room temperature and stirring overnight, the reaction solution was poured into ice water and extracted with chloroform. The organic layer was washed with water and saturated brine followed by drying with anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure and the resulting residue was purified by silica gel column chromatography (developing solvent: ethyl acetate/n- hexane = 1/1 (volume ratio)) to obtain 2.4 g of the target compound. Yield: 70% 1H-NMR (CDCl3, deltappm): 1.20(t,3H), 1.73-1.85(m,1H), 2.25(q,2H), 2.55-2.65(m,1H), 2.80-3.00(m,2H), 5.41-5.59(m,2H), 7.14(d,1H) 7.33(d,1H), 7.3 8(s,1H)
The synthetic route of 5-Bromo-2,3-dihydro-1H-inden-1-amine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nippon Soda Co., Ltd.; EP2186804; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary