These common heterocyclic compound, 1647-26-3, name is 1-Bromo-2-cyclohexylethane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Bromo-2-cyclohexylethane
To a solution of 1.22 g of 2-cyclohexylethyl bromide and 1.56 g ethyl N-[7-chloro-3-[2,3-O-(1-methylethylidene)-5-O-(2H-tetrahydropyran-2-yl)-beta-D-ribofuranosyl]-3H-imidazo[4,5-b]-pyridin-5-yl]-carbamate in 15 ml of dry dimethylformamide is added 0.25 g of sodium hydride (60% dispersion in mineral oil). After a few minutes the gas evolution subsides and the mixture is heated to 70 for 20 minutes. The reaction is quenched with water, and extracted three times with ethyl acetate. The organic extract is washed with water and dried (sodium sulfate). Evaporation of the solvent in vacuo gives an oil which is purified by flash chromatography on silica gel (40% ether/hexane followed by ether) to give ethyl N-[7-chloro-3-[2,3-O-(1-methylethylidene)-5-O-(2H-tetrahydropyran-2-yl)-beta-D-ribofuranosyl]-3H-imidazo[4,5-b]pyridin-5-yl]-N-(2-cyclohexylethyl)-carbamate.
The synthetic route of 1-Bromo-2-cyclohexylethane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Ciba-Geigy Corporation; US4977144; (1990); A;,
Bromide – Wikipedia,
bromide – Wiktionary