Adding a certain compound to certain chemical reactions, such as: 203302-95-8, name is 4-Bromo-3,5-difluoroaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 203302-95-8, Safety of 4-Bromo-3,5-difluoroaniline
In a re-sealable tube, to a solution of 4-bromo-3,5-difluoroaniline (500 mg; 2.40 mmol)[CAS 203302-95- 8] and N,N-disopropylethylamine (0.50 mL; 2.88 mmol) in tetrahydrofuran (5 mL) was added bromoacetonitrile (0.19 mL; 2.76 mmol). The tube was sealed and the solution was stirred at 80 C for 16 hours. The solvent was evaporated and the residue was purified by column chromatography (silica gel; petroleum ether:ethyl acetate; 2: 1; v/v) to afford 2-(4-bromo-3,5-difluoro-anilino)acetonitrile (160mg) as a light yellow solid. MS m/z (+ESI): 244.9, 246.9 [M+H]+. ‘H-NMR (400 MHz, CDC13) delta ppm: 6.32 – 6.37 (m, 2H), 4.26 – 4.31 (m, 1H), 4.10 (d, J = 6.8 Hz, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3,5-difluoroaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BASILEA PHARMACEUTICA INTERNATIONAL AG; LANE, Heidi; RICHALET, Florian; EL SHEMERLY, Mahmoud; (169 pag.)WO2018/2220; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary