Application of 40787-48-2,Some common heterocyclic compound, 40787-48-2, name is 1,4-Dibromo-2,5-diethylbenzene, molecular formula is C10H12Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In the glove box the mixture of 1 ,4-dibromo-2,5-diethylbenzene (7.1 1 g, 24.35mmol), 4-chloro-2-methylphenylboronic acid (8.3g,48.70mmol), Aliquat 336 (0.5g), and Pd(PPh3) (1 .4g, 1 .21 mmol, 0.05eq), and Na2CO3 (12.9g, 121 .7mmol) in degassed toluene (200mL) was prepared. Outside dry box, the degassed water (65ml_) was added to the former mixture under nitrogen, and then the resultant mixture was stirred at 88C overnight under nitrogen. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over anhydrous MgSO4. Filtration, concentration of the filtrate, and then the silica column chromatography (hexane) provided the desired product, 18, (6.7g, 72% yield) as a white solid.
The synthetic route of 40787-48-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; PARK, Kyung-Ho; RADU, Nora, Sabina; JOHANSSON, Gary, A.; FENNIMORE, Adam; DELANEY, William, J.; LECLOUX, Daniel, David; WO2011/159872; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary