Adding a certain compound to certain chemical reactions, such as: 1435-52-5, name is 1,4-Dibromo-2-fluorobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1435-52-5, Product Details of 1435-52-5
25.4 g (0.100 mol) 1 ,4-dibromo-2-fluorobezene, 24.4 g (0.100 mol) N-(3-chlorophenyl)-1 H- benzimidazol-2-amine and 63.7 g (0.300 mol) potassium phosphate tribasic in 130 ml DMA were stirred at 160 °C for 3 h under nitrogen. The reaction mixture was cooled to 25 °C. The Product was filtered off and was washed with water. The product was decocted in ethanol. Yield 34.5 g (87 percent). (0827) 1H NMR (400 MHz, CDCI3): delta = 7.99 (d, 1 H), 7.77-7.86 (m, 4H), 7.59 (t, 1 H), 7.34-7.51 (m, 5H).
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Reference:
Patent; IDEMITSU KOSAN CO., LTD.; SCHAeFER, Thomas; FLORES, Jean-Charles; NAGASHIMA, Hideaki; (236 pag.)WO2017/93958; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary