Synthetic Route of 13633-25-5, The chemical industry reduces the impact on the environment during synthesis 13633-25-5, name is 1-Bromo-4-phenylbutane, I believe this compound will play a more active role in future production and life.
General procedure: A mixture of the amine 9, alkyl bromide (1.2 equiv) and NaHCO3 (2 equiv) in DMF (20mL) was heated at 50C for 20h. After cooling to room temperature, the reaction mixture was poured into ice- H2O, and the product was extracted with Et2O. The ethereal extracts were washed with saturated NH4Cl solution, dried over Na2SO4, and the solvent was removed in vacuo to afford an oil. The crude oil was subjected to flash chromatography on silica gel using 75% EtOAc in hexanes as the eluent to give the 10-12 as solids.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-phenylbutane, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Iyer, Malliga R.; Rothman, Richard B.; Dersch, Christina M.; Jacobson, Arthur E.; Rice, Kenner C.; European Journal of Medicinal Chemistry; vol. 92; (2015); p. 531 – 539;,
Bromide – Wikipedia,
bromide – Wiktionary