Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1435-53-6, name is 2,4-Dibromo-1-fluorobenzene, A new synthetic method of this compound is introduced below., Computed Properties of C6H3Br2F
General procedure: To a mixture of 1,3-dibromo-5-fluorobenzene (1.39 g, 5.51 mM), 2-tri-n-butylstannylpyridine(5.00 g, 13.6 mM), bis(triphenylphosphine)palladium dichloride (1.00 g, 1.43 mM),and lithium chloride (0.37 g, 8.84 mM) in an oven dried Schlenk tube, distilled toluene(40 mL) was added. The mixture was degassed via the freeze-pump-thaw method until nogas bubbles were observed and refluxed at 110 C under nitrogen for 48 h. After coolingthe reaction mixture to room temperature, an aqueous solution of potassium fluoride(40 mL) was added and the insoluble black residue was filtered and washed with toluene.The toluene was removed under reduced pressure. Dichloromethane (100 mL) and aqueoussodium bicarbonate (100 mL) were added to the remaining residue. The organic phase wasseparated, washed with sodium bicarbonate (2 ¡Á 100 mL), then dried over anhydroussodium sulfate and evaporated to obtain a yellow residue. This residue was then purifiedover silica with a mixture of 90% hexane: 10% diethyl ether, whose mole fraction was measuredto 50% hexane: 50% diethyl ether to obtain a pale yellow solid (0.8078 g, 58%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Papo, Tshephiso R.; Jaganyi, Deogratius; Journal of Coordination Chemistry; vol. 68; 5; (2015); p. 794 – 807;,
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bromide – Wiktionary