Reference of 103273-01-4,Some common heterocyclic compound, 103273-01-4, name is 2-Bromo-4-(tert-butyl)aniline, molecular formula is C10H14BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2 – Bromo -4 -tert-butylaniline (2 – Bromo – 4 – tertbutylaniline) 40.0g (175.34 mmol), 4 – bromobenzoyl chloride (4 – Bromobenzoyl chloride) 38.4g (175.34 mmol) and THF 360 ml 3 hoursAfter completion of the reaction, the solvent was distilled under reduced pressure. A yellowish solid compound (intermediate (7)) 55.8g (=unitz ) was obtained by solid formation using diisopropyl ether (IPE) to give a solid compound having a yellowish 77.4% color.
The synthetic route of 103273-01-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Co., Ltd. Leputuo; Wu Weizhen; Han Jiazhong; Jin Huizhen; Jin Xiane; Jin Kuili; Ren Zhezhu; Xi Wenji; Gao Bingzhu; (46 pag.)CN109988119; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary