Adding a certain compound to certain chemical reactions, such as: 52548-00-2, name is 1-Bromo-4-fluoro-2,3-dimethylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52548-00-2, Recommanded Product: 52548-00-2
B. 3-Fluoro-o-xylene-6-boronic acid To a 125 mL three-necked round-boftomed flask equipped with septum and N2 inlet were added 4.08 g (20 mmol) 3-fluoro-6-bromo-o-xylene and 20 mL dry tetrahydrofuran. The solution cooled to -70 C., and 9.6 mL (24 mmol) of a 2.5 M solution of butyl lithium in hexane was added slowly over 5 minutes. The reaction was stirred 5 minutes at -70 C., then 4.08 mL (24 mmol) triethyl borate added, and stirring continued at -70 C. for 5 minutes. The reaction was then allowed to warm to room temperature and stirred for 16 hours, then poured into dilute hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, and evaporated. The residue was triturated with hexane to a white solid, 2.06 g (64%). 1H-NMR (delta, CDCl3): 2.22 (s, 3H), 2.30 (s, 3H), 6.7-7.3 (m, 2H). 13C-NMR (delta, CDCl3): 25.4, 26.3, 111.5, 111.7, 112.1, 112.3, 124.9, 126.0, 126.1, 130.8, 130.9,159.9,160.6, 162.3,163.0,.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-fluoro-2,3-dimethylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; VOLKMANN, ROBERT A.; LOWE III, JOHN A.; NOWAKOWSKI, JOLANTA; US2001/7873; (2001); A1;,
Bromide – Wikipedia,
bromide – Wiktionary