Related Products of 10546-67-5, These common heterocyclic compound, 10546-67-5, name is 2,6-Dibromo-4-(tert-butyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Take 3g of 2,6-dibromo-4-tert-butylaniline, 80mg of PdCl2(PPh3)2, 40mg of CuI, add 100mL of triethylamine, under argon protection, then slowly add 840mg of 2-methyl-3- Butyn-2-ol was stirred at 50 C for 60 hours. After the solution was cooled to room temperature, ethyl acetate was added to the reaction mixture, which was filtered. Then, it was extracted with dichloromethane and water, and the solvent was evaporated from dichloromethane.4-(2-Amino-3-bromo-5-(tert-butyl)phenyl)-2-methylbut-3-yn-2-ol(Compound of the formula (III)).
The synthetic route of 10546-67-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanxi Datong University; Yuan Yuehua; Zhu Yongjun; Tian Maozhong; Chen Zezhong; Qin Jun; Feng Feng; (15 pag.)CN109810019; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary