Adding a certain compound to certain chemical reactions, such as: 3972-64-3, name is 1-Bromo-3-(tert-butyl)benzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3972-64-3, Product Details of 3972-64-3
A 1. 6 M solution of nbutyllithium (12.0 mL, 19.2 mmol) was added to a solution of dicyclohexylamine (3.7 mL, 18.6 mmol) in toluene (40 mL). After stirring for 5 min, 3-methylene-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester (3.45 g, 14.4 mmol) was added. After stirring for 30 min, 1-bromo-3-tert-butyl- benzene (3.16 g, 14.8 mmol) was added followed by the simultaneous addition of tri-teff-butylphosphonium tetrafluoroborate (220 mg, 758, umol) and tris (dibenzylideneacetone) dipalladium (O)-chloroform adduct (380 mg, 367, umol). The solution was placed into a preheated oil bath at 60 °C. After stirring for 16 h, the solution was directly flash chromatographed with 99: 1,49 : 1,24 : 1, and 23: 2 hexanes/ethyl acetate as the eluant to yield 4.31 g (81 percent yield) of 1- (3-tert-butyl- phenyl)-3-methylene-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester as a light yellow oil.’H NMR (300 MHz, CDCl3) ; 6 7. 43 (d, J=1.0 Hz, 1 H), 7.25 (m, 3H), 4. 82 (s, 1 H), 4. 78 (s, 1H), 4.12 (m, 2H), 3.06 (d, J=13. 3 Hz, 1H), 2.52 (d, J=13. 3 Hz, 2H), 2.26 (dt, J=13.1 Hz and 4.5 Hz, 1H), 2.05 (m, 1H), 1.88-1. 59 (broad m, 3H), 1.31 (s, 9H), 0.89 (m, 2H),-0. 04 (s, 9H).
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Reference:
Patent; ELAN PHARMACEUTICALS, INC.; WO2005/87215; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary