Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 876-53-9, name is 1,3-Dibromoadamantane, A new synthetic method of this compound is introduced below., Application In Synthesis of 1,3-Dibromoadamantane
A compound of 1,3-dibromo-adamantane (3 g, 10 mmol) was dissolved in 30 mL of toluene, and then 250 mg of AIBN (1.5 mmol), 7 g of tri-n-butyl tin (24 mmol), 3 g of 2-ethyl methacrylate were added in order. The reaction was refluxed at 110 C. under nitrogen for 3 hours. The reaction solution was cooled to room temperature, and was poured into 30 mL of 0.2 M aqueous ammonia. After being stirred fully, the organic layer was separated, the aqueous layer was extracted with ethyl acetate (20 mL×4). The organic layers were combined, and washed with 30 mL of water and 30 mL of saturated sodium chloride solution, dried with anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give a crude product as a colorless oil, which was separated by silica column chromatography (petroleum ether:ethyl acetate=10:1) to obtain NM-012a as a colorless oil (1.6 g, 43.1%). ESI-MS: m/z 337.4 ([M+H]+). 1H-NMR (DMSO-d6, ppm): 0.97 (s, 2H), 1.02-1.08 (m, 8H), 1.15-1.20 (m, 7H), 1.22-1.40 (m, 7H), 1.50 (s, 2H), 1.57-1.65 (m, 2H), 1.93 (s, 2H), 2.39-2.47 (m, 2H), 3.98-4.11 (m, 4H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Guangzhou Magpie Pharmaceuticals Co., Ltd.; Wang, Yuqiang; Liu, Zheng; Yu, Pei; Sun, Yewei; Zhang, Zaijun; Zhang, Gaoxiao; Shan, Luchen; Yi, Peng; Larrick, James; (19 pag.)US2018/148404; (2018); A1;,
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