Electric Literature of 608-30-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 608-30-0 name is 2,6-Dibromoaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Under a nitrogen atmosphere, 1.2 mmol alpha,alpha-dione-2,3:5,6-bis(pentamethylene)pyridine, 1.0 mmol of CoCl2, 2.5 mmol of 2,6-dibromoaniline dissolved in 10mL glacial acetic acid, reflux reaction at 120 C (under reflux reaction) for 4 hours. After completion of the reaction, the mixture was cooled to room temperature, and 30 mL of anhydrous ether was added thereto, followed by stirring for 2 hours. Filtered, washed with ether and dried. A brown powder was obtained in a yield of 60.7%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,6-Dibromoaniline, and friends who are interested can also refer to it.
Reference:
Patent; Institute of Chemistry, Chinese Academy of Sciences; Du, Shizhen; Zhang, Wenjuan; Sun, Wenhua; (29 pag.)CN106432356; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary