In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 656-64-4 as follows. HPLC of Formula: C6H5BrFN
Compound IV (10g, 61.53mmol) was dissolved in ethanol (300 mL), add 3-bromo-4-fluoroaniline (. 1-V)(12.86 g, 67.68mmol), plus NaHC03. 3(12.92 g, 153.83mmol) Dissolved in 150mL water solution, heated to 60 ,TLC detection reaction, to be complete after the reaction of compound IV to stop the reaction.The solvent was distilled off under reduced pressure, the residue was extracted with ethyl acetate (100 mL)was dissolved, washed three times (30mL × 3), washed twice with saturated NaCl (30mL × 3), dried over anhydrous of Na2SO. 4dried overnight, solvent was distilled off under reduced pressure Recrystallization from ethyl acetate / n-hexane gave 8.03 g of a slightly yellow solid, 41.3% yield,
According to the analysis of related databases, 656-64-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; China Pharmaceutical University; Zhu Qihua; Fang Shengyang; Duan Qizhu; Xu Yungen; Jiang Zhenzhou; Heng Hao; Zhang Luyong; (15 pag.)CN106967004; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary