Adding a certain compound to certain chemical reactions, such as: 73918-56-6, name is 2-(4-Bromophenyl)ethanamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 73918-56-6, HPLC of Formula: C8H10BrN
To a solution of 2-(4-bromophenyl)ethan-1-amine (5.0 g, 25.0 mmol) in dichloroethane (100 ml), triethylamine (7.0 mL) and trifluoroacetic acid anhydride (7.88 g, 37.5 mmol) were added under ice cooling, and the mixture was stirred for 1 hour. Thereafter, the mixture was stirred at room temperature for further 3 hours. Under ice cooling, water was added to the reaction solution and, after stirring for 20 minutes, the mixture was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium bicarbonate, a saturated aqueous solution of ammonium chloride, and a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was dissolved in acetic acid (15 mL), fuming nitric acid (30 mL) was slowly added dropwise under ice cooling, and, thereafter, the reaction mixture was stirred under ice cooling for 1 hour and at room temperature for 16 hours. The reaction solution was poured onto ice and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium bicarbonate and a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by flash column chromatography to obtain N-[2-(4-bromo-3-nitrophenyl)ethyl]-2,2,2-trifluoroacetamide (5.17 g)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(4-Bromophenyl)ethanamine, and friends who are interested can also refer to it.
Reference:
Patent; TEIJIN PHARMA LIMITED; US2012/46467; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary