Reference of 3814-30-0, These common heterocyclic compound, 3814-30-0, name is (Bromomethyl)cyclopentane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 2-1 -1 Preparation of 4-({2-[1 -(cyclopentylmethyl)-1 H-indazol-3-yl]-5-methoxypyrimidin-4- yl}amino)pyridine-3-carboxamide 100 mg of 4-{[2-(1 H-lndazol-3-yl)-5-methoxypyrimidin-4-yl]amino}pyridine-3- carboxamide 1 -8-1 (277 muiotaetaomicronIota, 1 .0 eq.), 34 muIota_ (bromomethyl)cyclopentane (300 muetaiotaomicronIota, 1 .1 eq.) and 50 muIota_ 1 ,8-Diazabicyclo(5.4.0)undec-7-en (330 muiotaetaomicronIota, 1 .2 eq.) were dissolved in 2.1 mL DMF and stirred at rt for 3 days. The reaction mixture was diluted with water and ethyl acetate and extracted three times. The organic layers were washed once with water and brine, filtered through a silicon coated filter and concentrated in vacuo. The crude product was purified by HPLC-chromatography under basic conditions to provide the 96% pure target compounds: 12 mg, 30 muiotaetaomicronIota, 10% 1 H-NMR (400MHz, DMSO-d6) : delta [ppm]= ]= 1 .37 – 1 .49 (m, 2H), 1 .49 – 1 .62 (m, 2H), 1 .63 – 1 .76 (m, 4H), 2.54 – 2.63 (m, 1 H), 4.07 (s, 3H), 4.47 (d, 2H), 7.23 – 7.33 (m, 1 H), 7.42 – 7.52 (m, 1 H), 7.78 (d, 1 H), 7.89 (br. s, 1 H), 8.42 – 8.51 (m, 3H), 8.56 (d, 1 H), 8.97 (S, 1 H), 9.32 (d, 1 H), 12.17 (s, 1 H).
The synthetic route of 3814-30-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HITCHCOCK, Marion; MENGEL, Anne; MUeLLER, Thomas; BAeRFACKER, Lars; CLEVE, Arwed; BRIEM, Hans; SIEMEISTER, Gerhard; BONE, Wilhelm; FERNANDEZ-MONTALVAN, Amaury, Ernesto; SCHROeDER, Jens; MOeNNING, Ursula; HOLTON, Simon; PREUSSE, Cornelia; (165 pag.)WO2017/157991; (2017); A1;,
Bromide – Wikipedia,
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