Synthetic Route of 129316-09-2, These common heterocyclic compound, 129316-09-2, name is 1,3-Dibromo-5-(tert-butyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 : 1-Bromo-3-(tert-butyl)-5-(prop-1-en-2-vnbenzene (P24a)To a solution of 1 ,3-dibromo-5-(terf-butyl)benzene (2.92 g, 10 mmol) in dioxane (20 mL) was added Pd(PPh3)4 (3.0 g, 2.6 mmol), prop-1-en-2-ylboronic acid (1.0 g, 12 mmol), K2C03 (2.8 g, 20 mmol) and H20 (1 mL) under N2. The resulting mixture was stirred at 90C overnight, concentrated and purified by CC (hexane) to give compound P24a (2.5 g, 100%; 80% by GC/MS) as a liquid.
Statistics shows that 1,3-Dibromo-5-(tert-butyl)benzene is playing an increasingly important role. we look forward to future research findings about 129316-09-2.
Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas; WO2012/139775; (2012); A1;,
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