Application of 57190-17-7,Some common heterocyclic compound, 57190-17-7, name is 2-Bromo-1,3-diisopropylbenzene, molecular formula is C12H17Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Add 2.92 g (0.12 mol) of magnesium shoulder and 0.05 g of crystalline iodine to a 250 mL four-neck round bottom flask under nitrogen24. A solution of lg (0.1 mol) of 2,6-diisopropylbromobenzene, 34.5 g (0.15 mol) of n-butyl borate and 75 mL of anhydrous tetrahydrofuran was dropped into the flask. The temperature of the water bath was 25 C, the reaction started, the color of iodine disappeared, and the temperature of the solution increased. Adjust the drop rate to keep the temperature of the solution at around 30 C, about 1 hour. After the completion of the dropwise addition, the mixture was stirred for 1 hour to obtain a solution 2. The solution 2 was poured into 100 mL of 4 wt.% of 0″ hydrochloric acid and stirred for 30 min. After standing, the organic layer was separated, and the aqueous layer was extracted with diethyl ether (100 mL×3 times). The organic layer was combined and the solvent was evaporated under reduced pressure. The water was adjusted to RhoEta=10 with sodium hydroxide solution. The butanol and the like were removed by steam distillation under reduced pressure (40-50 C), filtered while hot, and the filtrate was acidified to pH Eta = 2, crystals were precipitated, cooled, and suction filtered. Dry to constant weight.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromo-1,3-diisopropylbenzene, its application will become more common.
Reference:
Patent; Nanjing Medical University; Li Fei; Chen Dongyin; Yang Lei; Dong Zezhong; Zhou Yu; Luo Chunxia; Jiang Nan; Li Tingyou; Qin Yajuan; (6 pag.)CN108774254; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary