Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 176317-02-5, name is 1-Bromo-2,3,4-trifluorobenzene, A new synthetic method of this compound is introduced below., name: 1-Bromo-2,3,4-trifluorobenzene
To a solution of isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran (1.3 M, 5.68 ml, 7.4 mmol) was added i-bromo-2,3,4-trifluorobenzene (1.5 g, 7.04 mmol) dissolved in dry tetrahydrofuran (3 ml) and the mixture was stirred under nitrogen at ambient temperature for2.5 hours. The reaction mixture was cooled to -10 00 and tert-butyl 3-formylazetidine-i- carboxylate (1 .41 g, 7.4 mmol) dissolved in dry tetrahydrofuran (3 ml) was added in one portion and the temperature was raised to 0 00 and stirred for 20 mm and then brought to ambient temperature and stirred for additional 30 mm. The reaction mixture was quenched with saturated ammonium chloride solution and extracted with ethyl acetate. The pooled organicphase was washed with brine, dried (Na2504, filtered and evaporated to dryness. The crudeproduct was further purified by flash column chromatography on silica gel (iso-octane: ethylacetate, 100:0 to 70:30) to give the title compound (2.0 g, 6.3 mmol). MS mlz (rel. intensity, 70eV) 317 (M+, 2), 262 (29), 243 (18), 171 (81), 57 (bp)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; INTEGRATIVE RESEARCH LABORATORIES SWEDEN AB; PETTERSSON, Fredrik; SONESSON, Clas; (79 pag.)WO2016/185032; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary