608-30-0, name is 2,6-Dibromoaniline, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 2,6-Dibromoaniline
Example 15 In this example, formation of 2,6,2″,6″-tetramethoxy-[1,1′;3′,1″]terphenyl-2′-ylamine is shown. 25.0 g (0.137 mol) of 2,6-dimethoxyphenylboronic acid, 11.41 g (0.046 mol) of 2,6-dibromo-phenylamine, 54.00 g (0.166 mol) of cesium carbonate, 0.62 g (0.000677 mol) of tris(dibenzylideneacetone)dipalladium (0), 0.38 g (0.00163 mol) of di-tert-butyl-trimethylsilanylmethyl-phosphine and 125 ml of dioxane were stirred at room temperature for 12 hours. The reaction mixture was filtered and the solvent was removed under vacuum. The resulting mixture was recrystallized from methylene chloride. Yield of 2,6,2″,6″-tetramethoxy-[1,1′;3′,1″]terphenyl-2′-ylamine was 12.21 g (73%) with m.p. 177.77 C. 1H NMR (CDCl3) 3.95 (s, 12H, MeO), 4.10 (s, 2H, NH2), 6.85-7.60 (m, arom. 9H).Anal. Calcd. for C22H23NO4: C, 72.31; H, 6.34; N, 3.83. Found: C, 72.13; H, 6.28; N, 3.02. GC/MS MW is 365. The structure was confirmed by X-ray analysis.
The synthetic route of 608-30-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Ionkin, Alex Sergey; US2006/281923; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary