Synthetic Route of 766-81-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 766-81-4, name is 3-Bromophenylacetylene, This compound has unique chemical properties. The synthetic route is as follows.
In 25 ml in the reactor, adding O-bromophenyl (0.034 g, 0.2 mmol) and cuprous iodide (0.004 g, 0 . 02 mmol) butyl potassium (0.045 g, 0.4 mmol), vacuum replace the nitrogen after three times by adding 3 – bromophenylacetic acetylene (0.054 g, 0.3 mmol) and water (0.015 g, 0.8 mmol), in anhydrous 1, 4 – dioxane 1.5 ml, 110 C under stirring 16 h after. Column chromatography (silica gel, 200 – 300 mesh; developing agent, petroleum ether: ethyl acetate=5:1) to obtain 3 – (3 – bromophenylacetic methylene) isoindoline -1 – one 0.042 g, yield 70%.
The chemical industry reduces the impact on the environment during synthesis 3-Bromophenylacetylene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Dalian University of Technology; Bao Ming; Li Pengcheng; Zhang Sheng; Wang Wanhui; (24 pag.)CN109912492; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary