Reference of 2550-36-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2550-36-9 name is (Bromomethyl)cyclohexane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 1: To a solution of 3-bromo-6-methylimidazo[1 ,5-a]pyrazin-8(7H)-one (1 g, 4.39 mmol, 1 eq) and Cs2003 (2.86 g, 8.78 mmol, 2 eq) in DMF (20 mL) was added (bromomethyl)cyclohexane (1 .55 g, 8.78 mmol, 1.22 mL, 2 eq). The mixture was stirred at6000 for 18 hour. The reaction mixture was filtered and the filtrate was concentrated. The crude mixture was purified by flash chromatography with petroleum ether:ethyl acetate = 5:1 3:1. 3-bromo-7-(cyclohexylmethyl)-6-methylimidazo[1 ,5-a]pyrazin-8(7H)-one (1 g, 3.02 mmol, 69% yield) was obtained.1H NMR (ODd3, 400 MHz): 7.86 (s, 1H), 6.80 (s, 1H), 3.79 (d, J= 7.2 Hz, 2H), 2.29 (s,3H), 1.75 -1.66 (m, 6H), 1.22 – 1.04 (m, 5H).LC-MS: tR = 0.791 mm (method 15), mlz= 325.9 [M + H].
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (Bromomethyl)cyclohexane, and friends who are interested can also refer to it.
Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; LANGGARD, Morten; JESSING, Mikkel; VITAL, Paulo, Jorge, Vieira; JUHL, Karsten; (159 pag.)WO2016/174188; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary