327-51-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Into a three-necked flask, 1,4-dibromo-2,5-difluorobenzene (5.4g, 20.0mmol), compound 27 (16.1g, 42.0mmol), 2M Na2CO3 aqueous solution (40mL, 80.0mmol), DME (40mL), toluene (40mL ), Pd[PPh3]4 (1.2g, 1.0mmol) were mixed, this mixture was refluxed for 8 hr under Ar atmosphere. After the reaction was cooled to room temperature. The sample was transferred to a separatory funnel, added water (100mL), extracted with CH2Cl2 and dried in. MgSO4, filtered, and concentrated. Purifying the sample by silica gel column chromatography to obtain a white solid. Yield 11.8g, 75% yield
The synthetic route of 327-51-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Idemitsu Kosan Corporation; Kato, Tomoki; Numata, Masaki; Yoshida, K.; Nishimura, Kazuki; Eiwakuma, Toshihiro; Hosokawa, Chisio; (108 pag.)KR101500796; (2015); B1;,
Bromide – Wikipedia,
bromide – Wiktionary