In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 103273-01-4 as follows. Formula: C10H14BrN
General procedure: A Schlenk tube containing Pd(OAc)2 (24.3 mg, 0.108 mmol), K2CO3 (759mg, 5.49 mmol), tricyclohexylphosphine (61.7 mg, 0.220 mmol), anddiphenylacetylene (470 mg, 2.58 mmol) was flushed with N2. NMP (21mL) and 2-bromo-5-tert-butylaniline (525 mg, 2.30 mmol) was added andthe resulting mixture was heated to 110 C. After stirred for 18 h, themixture was cooled to room temperature and then filtered through a shortpad of Celite with EtOAc. The eluent was washed with water and brine,dried over anhydrous Na2SO4, and evaporated to dryness. Purification bysilica-gel column chromatography (hexane/EtOAc as an eluent) afforded1a (460 mg, 1.42 mmol) in 62% yield.
According to the analysis of related databases, 103273-01-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Shigeno, Ami; Matsuno, Takashi; Hiroto, Satoru; Shinokubo, Hiroshi; Chemistry Letters; vol. 44; 12; (2015); p. 1703 – 1705;,
Bromide – Wikipedia,
bromide – Wiktionary