3972-65-4, name is 1-Bromo-4-(tert-butyl)benzene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 3972-65-4
In a J.T. Young tube, 0.75 mmol of olefinic compound, 0.5 mmol of aryl halide, 0.6 mmol of potassium carbonate, 0.005 mmol of triphenylphosphite, 0.0005 mmol of Pd(dba)2 or the respective palladium source, and 0.1 mmol of trans-stilbene (as internal standard) were dissolved in 1 mL of DMF under nitrogen atmosphere. The tube was sealed and before putting it into a 100 C hot bath of silicon oil, it was purged three times carrying out cycles of vacuum/nitrogen. After 20 h of continuous stirring the mixture was cooled to room temperature and 0.5 mL of 2 M HCl and 0.5 mL ofdichloromethane were added. The organic phase was analyzed by GC. The products were crystallized from methanol/dichloromethane cold mixtures and characterized by 1H NMR, GC-MS, IR, and mp and compared with the reported spectra.
Statistics shows that 3972-65-4 is playing an increasingly important role. we look forward to future research findings about 1-Bromo-4-(tert-butyl)benzene.
Reference:
Article; Cardenas, Juan C.; Fadini, Luca; Sierra, Cesar A.; Tetrahedron Letters; vol. 51; 52; (2010); p. 6867 – 6870;,
Bromide – Wikipedia,
bromide – Wiktionary