Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1073-06-9, name is 1-Bromo-3-fluorobenzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Bromo-3-fluorobenzene
General procedure: An argon filled 50 mL two-necked flask equipped with stir barand a gas condenser was charged with magnesium turnings(165 mg, 6.800 mmol). After three successive vacuum/argon cycles,THF (15 mL) and one grain of iodine were added, and brownishsuspension was stirred for 15 min at room temperature. Subsequentlyfluorinated bromobenzene (6.700 mmol) was added. Anexothermic reaction was followed by changes of the color of thereaction mixture from original brown, through colorless to finalgrayish. This suspension was stirred 2 h at room temperature andthen cooled to 50 C. A white solid precipitated. Subsequently,methyl 2-formylbenzoate (20) (500 mg, 3.046 mmol) was addedinto vigorously stirred suspension. Cooling was stopped and thereaction mixture was slowly allowed to reach room temperatureand then stirred for additional 16 h. The suspension dissolved atca 5 C leaving dark red solution, which then slowly changed colorto orange and the dense yellowish solid slowly precipitated duringsubsequent stirring. Then Ac2O (4 mL) was added dropwise (thesuspension dissolved leaving a clear yellow/orange solution) andthe reaction mixturewas refluxed at the temperature of the oil bath 70 C for additional 30 min. A dense yellowish precipitate wasformed again. Yellow suspension was cooled to room temperature,diluted with ether (100 mL), and washed with a saturated aqueoussolution of NaHCO3 (3 15 mL). Deep yellow organic phase wasdried over MgSO4. Solvents were removed under reduced pressureand column chromatography on silica gel (hexane/ethyl-acetate -4:1) afforded products as yellow crystalline solids.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Kaleta, Ji?i; ?imkova, Ludmila; Li?ka, Alan; Bim, Daniel; Madridejos, Jenica M.L.; Pohl; Ruli?ek, Lubomir; Michl; Ludvik, Ji?i; Electrochimica Acta; vol. 321; (2019);,
Bromide – Wikipedia,
bromide – Wiktionary